Methotrexate: The other side of the story

I recently saw a couple of stories (here and here) that piqued my interest. They both dealt with shortages of a drug called Methotrexate. Wanting to know more, I spoke to a friend who happens to be a pharmacist. Here is what I learned.

  • Methotrexate is a fifty-year-old chemotherapy drug that is still used to treat certain types of cancers, such as ALL
  • The patent has long since expired and it is cheaply available as a generic – a single dose costs about $1.58.
  • It is possible to source Methotrexate from overseas, but there are justifiable concerns about quality control
  • It is possible to source Methotrexate on the black market – a $15 bottle costs $85.

Why is there a shortage of this drug? Because the pharmaceutical companies in the US have stopped making it.

Why have they stopped making it? Because it is no longer profitable for them to do so.

Why is it no longer profitable? Because the government expects to purchase their supply below cost.

In most cases, this is not a problem; the private market pays a higher rate that makes the drug profitable. But since the vast majority of the Methotrexate consumed in the US is by Medicare and Medicaid, there is not enough money on the table to make it cost-effective to produce the stuff.

So there you have it. The Government has decided on how much they are willing to pay for Methotrexate, and the suppliers say that they cannot produce it at that cost while making enough profit to make it worth their while.

Amazingly, the commonest solution that I have heard is that we must somehow force the companies to supply Methotrexate at the desired price. And yet, if you ask people if they are willing to go to work for nothing, they will look at you as if you were insane. But what they are asking for is pretty much the same thing.

This is where Keynesian economics falls flat on its face – the government can mandate whatever price it wants, but the one thing it cannot do – at least for long – is to force a business to sell a product to them at a loss. And that appears to be what has happened here.

Sadly, the press is not reporting this side of the story; they ‘re too busy telling us about the eeeevil pharmaceutical companies, and showing us pictures of cute bald children suffering from leukemia.

Did I miss something?

Post a comment or leave a trackback: Trackback URL.


  • Jenny Pinto  On March 22, 2012 at 5:43 AM

    Major reasons are also leads to shortages of medicines such as if drugs are available but in less stock to supply, increase in demand of that medicines or stop manufacturing that drugs for certain period of time because of quality control issues. But if you read this where Superdrugsaver are providing free Methotrexate medicine to help Leukemia cancer patients.

    • Wizard Prang  On March 26, 2012 at 2:40 PM

      Jenny, as I mentioned, the shortage is restricted to the US. Methotrexate is available overseas — there is no shortage, for instance, in Britain — which leaves your explanation somewhat lacking.

      I am not an expert on this subject, so I spoke with several people who are, including a Pharmacist for a University Hospital and several nurses. They, too, expressed disdain at the “supply” and “quality control” excuses. One even compared them to Big Oil’s “excuse du jour” explanation of why petrol prices have to go up. All of them agreed that Government Price controls have a huge effect on the pharmaceutical industry — and it is not always a salutary one.

      It is great that SDS is offering free Methotrexate. Sadly, this is a limited quantity for a limited time — which looks like a marketing move, to me.

      And it does not change anything that I have said.

Leave a Reply

Please log in using one of these methods to post your comment: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s

%d bloggers like this: